Endocrine Abstracts

Introduction: Gastric bypass surgery in obese patients results in weight loss, changes in gastrointestinal and pancreatic hormones and improvement of insulin sensitivity.Methods: GLP-1, insulin and glucose levels were measured after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5, 90 and 180 days after gastric bypass surgery. Glycaemia (mmol/l; glucose oxidase);GLP-1 (Active 7–36) (pM/l; ...

Myxoid adrenocortical adenoma is a rare adenoma originated from adrenal cortex. A 51 years old male patient was admitted to our hospital due to hypertension and hypokalemia. He has a long history of nonregulated hypertension despite multiple antihypertensive medications. Hypokalemia was detected in last two years with potassium levels around 3.0 mmol/l on high supplementation dose up to 10–16 g of KCl/day. He is obese in the past 10 years. His family history was positive...

Objective: It has been difficult to identify factors that affect the risk of cancer but we know that people are at higher risk as they get older, or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood.Aim: To study associations between PA and family history of malignancy in first-degree and second-degree relatives. As separate analysis, to study associations between PA patients...

Introduction: Glucocorticoids (GC) are the first line treatment for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined. The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period.Methods: The study includes 50 patients (48±10 years; 37 females) with untreated, active and moderate-to-severe GO. Patient...

Thyroid dysfunction has been linked to reduced fertility. It is known that changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism. It is also has reported that women with polycystic ovary syndrome (PCOS) are more insulin-resistant than it would be expected on the basis of their age and BMI. The mechanisms underlying this phenomenon are still not clarified. Hyperandrogenaemia may play a role, but also other factors such as thyroid fu...

Introduction: Changes in thyroid function have significant impact on the cardiovascular system.Methods: In a group of 37 subjects the level of thyroid hormones FT4, FT3, and TSH were measured. Then carried out short-term analysis for 30 min measureing variability of blood pressure with non-invasive TASK FORCE monitor. Registered data were analyzed by spectral analysis of variability. Statistical analysis were done by Pearson correla...

The pandemic increase of obesity, malnutrition and associated comorbidities encouraged intensive studies on energy balance control. Ghrelin is a brain-gut orexigenic hormone that is involved in both the short-term and long-term regulation of energy homeostasis. The aim of this research was to investigate the role of centrally applied ghrelin on the pituitary morphofunctional features and corticosterone secretion in normal-fed, food-restricted and obese 8 weeks old Wistar male ...

It is well known that weight losses in the range of 2.5–5% are able to improve factors of the metabolic syndrome such as insulin sensitivity. Several studies have been published concerning weight loss and subsequent changes in inflammatory markers and indicate that higher weight losses are necessary to affect the inflammatory markers than are needed to affect insulin sensitivity. Some data showed impairment of insulin sensitivity in diabetic patients during starvation. Th...

C-reactive protein (CRP) is closely associated with obesity and cardiovascular disease in both diabetic and nondiabetic subjects. The aim of our study was to investigate the effects of commonly prescribed antidiabetic agent metformin on CRP and insulin sensitivity in type 2 diabetes patients after 12 weeks of therapy. Twenty-three newly diagnosed type 2 diabetic patients (mean age: 49.74±2.03 years; mean BMI: 31.40±1.27 kg/m2) have been given metformin 2 g...

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and acute insulin response (AIR) in patients with PHPT.Methods: In patients with PHPT (n=37; age: 57.72±8.29 years, BMI 26.22±4.37 kg/m2) euglycemic–hyp...